The role of International Governmental and Non-Governmental Organizations all over the world cannot be under estimated, this is because their role in lives building, hope assurance and reassurance is something to reckon with. This paper, however, was designed to periscope and x-ray the role of some of this humanitarian agency in mitigating poverty and engendering the lives of the most needy and vulnerable one’s globally. Though avalanche of agencies is bound in today contemporary world, but the authors of this paper purposively sample out USAID, and a Faith-Based (Caritas International) Organisation for comparative analyses. The paper was divided into four interrelated part starting with the introduction. The second part dealt with historical development of Caritas as well as his effort so far in mitigating global problems. Phase three, was a narration of USAID emergence as well as its effort toward humanitarian assistance, its area of concern was also identified as well as prioritization of the institution by the U.S government, part four of the paper focus on USAID-Caritas struggle for hegemony and the shifting points. The paper strictly relied on used of secondary source for generating material, while method of content analysis was used in analyzing the findings. the paper, haven comparatively dissect the two agency, argued that in spite of the magnitude of the resource based in the bag of USAID, the agency over the years has been declining in its duty and such a setback was seen as a result of state progressive interferences in the agency, lack of project compatibility, fear of intrusion, double standard act of the agency to mention but a few.